Advances in Androgen Receptor Antagonists
نویسندگان
چکیده
منابع مشابه
Androgen receptor antagonists (antiandrogens): structure-activity relationships.
Prostate cancer, acne, seborrhea, hirsutism, and androgenic alopecia are well recognized to depend upon an excess or increased sensitivity to androgens or to be at least sensitive to androgens. It thus seems logical to use antiandrogens as therapeutic agents to prevent androgens from binding to the androgen receptor. The two predominant naturally occurring androgens are testosterone (T) and dih...
متن کاملAndrogen Receptor Antagonists Suppress Immunotherapy in Prostate Cancer.
Surgical castration synergizes with immunotherapy, but chemical castration has suppressive effects.
متن کاملClassification and Virtual Screening of Androgen Receptor Antagonists
Computational tools, such as quantitative structure-activity relationship (QSAR), are highly useful as screening support for prioritization of substances of very high concern (SVHC). From the practical point of view, QSAR models should be effective to pick out more active rather than inactive compounds, expressed as sensitivity in classification works. This research investigates the classificat...
متن کاملP-231: Androgen Receptor Gene Expression in Azoospermia Men
Background: Androgens are critical steroid hormones in progression of spermatogenesis process and determine the male phenotype that their actions are mediated by the androgen receptor (AR), a member of the nuclear receptor superfamily. In the Androgen receptor, transactivation domain encoded by exon 1, DNA binding domain encoded by exons 2 and 3, hinge region encoded by part of exon 4, and C-te...
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ژورنال
عنوان ژورنال: AACR Education book
سال: 2012
ISSN: 1943-6475
DOI: 10.1158/aacr.edb-12-8402